Manchester United Under-21s stand between Wanderers and a place in the Papa Johns Trophy quarter-final.
The Whites haven’t faced the Manchester club at senior level in more than a decade.
Tom Huddlestone has played for the United youngsters in the Papa Johns Trophy this term as part of his new role as a player-coach.
The midfielder had spells with Tottenham and Hull among others and even represented England on several occasions.
His current role is similar to Andrew Tutte’s at Wanderers, coaching the young talent and helping them learn on the pitch.
Huddlestone played just over an hour against Wolves Under-21s in the previous round before he was replaced by Rhys Bennett.
Alejandro Garnacho has also featured in the Papa Johns Trophy this season, scoring in the 2-1 win against Barrow.
The highly rated 18-year-old has made 10 first-team appearances since the start of the campaign and was on target in the 2-1 victory at Fulham in the Premier League last month, keeping his composure to slot home the winner in stoppage time.
He also scored the decisive goal in the 1-0 win against Spanish outfit Real Sociedad in the Europa League group stage a week earlier.
Other members of the squad include Marc Jurado, who signed from Barcelona, and Charlie Savage, the son of former Blackburn and Derby midfielder Robbie Savage.
There is also a chance United might use the fixture as an opportunity to field a couple of first-team players who have not been involved in the World Cup in Qatar.
The Premier League season does not resume until Boxing Day but Erik ten Hag’s side also have a Carabao Cup match against Burnley coming up next week.
Tickets for Tuesday night’s fixture will remain on sale until kick-off and are priced at £10 for adults and £5 for over-65s and under-18s.
Only the lower tier of the Nat Lofthouse Stand will be open pending demand, and it is worth nothing that there will be no cash turnstiles in operation.
Wanderers reached this stage thanks to a 3-2 win against League Two outfit Barrow last month after goals from Dapo Afolayan, Jon Dadi Bodvarsson and Elias Kachunga.
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