Wanderers will face an under-strength Arsenal team in Saturday's FA Cup tie at the Reebok.
Thierry Henry was already doubtful with a hamstring injury he sustained in Tuesday night's Carling Cup upset against Wigan at Highbury but Gunners boss, Arsene Wenger, is planning to rest more of his regulars in the hope of keeping his squad fresh for the Premiership.
"On Saturday we will rest many players, like Lauren, (Sol) Campbell and Henry, because we have many injuries and problems - we will not take a chance in the FA Cup," he said.
"We will focus on the Premiership and try to get into the Champions League."
Wenger at least has scope to ring the changes, unlike Sam Allardyce, whose selection options are seriously restricted by African Cup of Nations calls and injuries.
Hidetoshi Nakata, suspended when Wanderers beat Manchester City on Saturday, is expected to return for the injured Khalilou Fadiga in an otherwise unchanged team.
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