Wanderers will be looking to avoid a repeat of last season's FA Cup defeat to Arsenal when the two sides meet in this season's competition.
The Whites get a quick opportunity to eradicate the memory of the miserable sixth round defeat to the Gunners when they meet again at the Reebok on the weekend of January 28.
The fourth round clash against the cup holders will be eagerly anticipated at the Reebok, where Sam Allardyce's men suffered a 1-0 defeat in an incident-packed clash last March.
It was 10-man Wanderers who went down fighting after El-Hadji Diouf got himself sent off after lashing out at Arsenal goalkeeper Jens Lehmann after just nine minutes.
The Gunners had taken the lead six minutes earlier through Freddie Ljungberg and Diouf's dismissal left Wanderers needing a footballing miracle to progress to the semi-finals.
Diouf will not get the chance to make amends as he will be representing Senegal in the African Cup of Nations along with Abdoulaye Faye while Nigerian Jay Jay Okocha and Tunisian Radhi Jaidi will also still be away.
Wanderers proved at Watford in Saturday's third round that they are able to compete when not at full strength and Arsenal will come to the Reebok knowing they are in for a tough game.
Experience of recent visits to the Reebok have taught the Gunners never to take the Whites lightly.
Arsene Wenger's men have a poor Premiership record at Bolton of late, losing on their last two league visits and drawing the previous two. Wanderers' unbeaten home league run against Arsenal began in rousing circumstances towards the end of the 2002/03 season.
Wanderers stormed back from two goals down to force a 2-2 draw, in what Wenger later admitted was the game that cost his side the Premiership title.
In other ties, Burton landed a dream tie against another Midlands club Wolves.
But the part-timers, who held Manchester United to a goalless draw, have first to get past Sir Alex Ferguson's side in next week's replay at Old Trafford.
Giant-killing Orient were planning another upset against Barclays Premiership opposition.
The Os put paid to Fulham and have been handed a fourth-round trip to Charlton.
Their midfielder Craig Easton said: "We are happy with Charlton. We're away again but we'll approach it the same, and you never know what can happen. We'll give it our best shot."
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